577-2297
nraz@wayne.edu
226 Knapp

Dr. Raz completed his undergraduate studies at Hebrew University in Jerusalem in 1979.  He was trained in psychology and human neuroscience at the University of Texas at Austin. and received his Ph.D. in 1985. Dr. Raz's research focuses on the neural correlates and modifiers of cognitive aging. His research has been continuously supported since 1993 by the National Institute on Aging.

Research Focus

The main themes in the current studies in Dr. Raz's lab are:

• Differential aging of brain structure. The emphasis is on longitudinal approach to study of change and variability in the rates of change in regional brain volumes as well as regional integrity of the cerebite matter. The results of our previous studies (cross sectional comparisons and longitudinal follow-up) indicate that not all brain components age at the same rate. Association cortices, the caudate nucleus, the hippocampus and the cerebellum show steeper declines than the visual cortex, the entorhinal cortex and the pons. We are trying to identify the antecedents of change and the morifiers of the age trajectories of structural brain declines.
• Cognitive consequences of structural brain aging. Although structural changes may be separated by cognitive declines by a long time period, some links between smaller regional volumes or faster longitudinal declines of brain regions and poorer performance on cognitive tasks have been noted. For example, we found that smaller prefrontal volumes are associated with greater difficulty to abandon previously reinforced but currently maladaptive cognitive strategy (Raz et al., 1998; Gunning-Dixon & Raz, 2003). Smaller putamen and cerebellar hemispheres are linked to poorer performance on perceptual-motor task (Raz et al., 2000), and the rate of shrinkage in usually stable entorhinal cortex is associated with reduced memory performance (Rodrigue & Raz, 2006).

• Modifiers of brain aging:
  • Negative modifiers
    Hypertension, even when treated and reasonably well controlled, may still exert negative influence on the brain. We observed, however, that those negative effects are limited to the executive functions and the regions of their brain substrate - the anterior part of the frontal lobes (Raz et al, 2003). Sometimes, removal of mildly hypertensive subjects from a sample reduces age-related differences. We are currently attempting to replicate these findings and to examine possible mediators of the effects of mild hypertension on brain and cognition.
  • Positive modifiers
    Exercise is known to alleviate some of the effects of cardiovascular risk factors on many organs and systems, including the brain.
     
  • Genetic modifiers. Multiple genes control complex cognitive fuinctions and their brain substrates. Naturally occuring variants of specific genes affect production and expression of neurochemical compounds that modify neuroanatomy and behavior. Although those variants account for a small percentage of individual variation in brain and cognition, they are nonetheless important contributors to the emrging pattern of individual differences in human aging. For example, COMT Val158Met polymorphisms was found to affect executive functions, and in our sample, Met allele homozygotes performed better than Val allele carriers on several executive tests as well as more complex tests of fluid abilities. Selective executive functions are also affected by epsilon4 allele of ApoE polymorphisms known to increase the risk for Alzheimer’s disease. We are currently examining the effects of polymorphisms associated with vascular risk and inflammatory processes as candidates for explaining age-related differences in brain and cognition.  For instance, a variant in the gene that controls expression of Brain-Derived Neurotrophic Factor (BDNF) modifies memory performance in healthy adults. Notably, that variant (a met allele of the BDNF val66met polymorphism) may be more harmful to memory performance when it is combined with a modifiable vascular risk factor such as elevated (though nominally normal) blood glucose (Raz et al., 2008 Front Human Neurosci). Hence our interest in combined or synergistic influence of genetic and physiologicalvascular risk factors on brain and cognition in the context of aging.

Courses Taught

Undergraduate

    Physiological Psychology

Graduate

Neuropathology and Behavior PSY7340

Cognitive Neuroscience

Functional Neuroanatomy PSY8060 (with Brain Dissection lab)

 

 

 

Training Offered

In the Cognitive Neuroscience of Aging Laboratory, graduate students acquire a wide range of research skills. Their training includes computer-aided processing and analysis of MRI images, design and administration of cognitive and neuropsychological tests and statistical analysis. Our neuroimaging projects are conducted at the Wayne State University MRI Center in collaboration with E. Mark Haacke, Ph.D. http://www.mrimaging.com/images/website/File/4th%20Edition%20-%20SWI%20Brochure%20-%202006,%20May%203.pdf

Current graduate students in the lab:

• Cheryl L. Dahle -  ak0174@wayne.edu
• Andrew Bender -  aw4734@wayne.edu
• Yiquin Yang  aw5311@wayne.edu
• Peng Yuan du3788@wayne.edu
  
• Ana M. Daugherty dy6149@wayne.edu 

Alumni of the CNA Lab

• Ivan J. Torres, Ph.D. 1993. Associate Professor, LT Department of Psychology, Simon Fraser University, Burnaby, BC, Canada http://www.psyc.sfu.ca/people/faculty.php?topic=finf&id=45
• Allen E. Thornton, Ph.D. 1995. Assistant Professor, Department of Psychology, Simon Fraser University, Burnaby, BC, Canada aethornt@sfu.ca web page:http://www.sfu.ca/psyc/faculty/thorntona/
• Wendy Loken-Thorton, Ph.D. 1995. Assistant Professor, Department of Psychology, Simon Fraser University, Burnaby, BC, Canada wthornto@sfu.ca web: http://www.psyc.sfu.ca/people/faculty.php?topic=finf&id=65
• Faith Gunning-Dixon, Ph.D. 2000. Assistant Professor, Department of Psychiatry, Cornell University Weill Medical College fgd2002@med.cornell.edu web: http://www.med.cornell.edu/research/fgdixon/index.html
• Denise Head, Ph.D. 2001. Assistant Professor, Department of Psychology, Washington University.dhead@artsci.wustl.edu web: http://hrl.wustl.edu/labmembers/current.html
• Karen Rodrigue, Ph.D  2007 Research Associate, Universityof Texas at Dallas, http://www.brainhealth.utdallas.edu/  krodrigue@utdallase.edu
• Kristen Kennedy , Ph.D. 2007 Research Associate, University of Texas at Dallas,  http://www.brainhealth.utdallas.edu/  http://agingmind.utdallas.edu/whoweare_kristen.php kristen.kennedy1@utdallas.edu

Research Project Title

Neural Corelates and Modifiers of Cognitive Aging

Grants

• National Institute on Aging, grant 2R37AG011230 Neural Correlates and Modifiers of Cognitive Aging. Funding period: 7/1/05-6/30/10, direct costs: $2,090,389, a MERIT award.
  
• National Institute on Aging, grant R03-AG024630 Hemodynamic predictors of brain and cognitive aging. $117,000 direct costs, funding period September 15, 2004 - June 30, 2006

Professional Associations

American Association for Advancement of Science
Cognitive Neuroscience Society
Memory Disorders Research Society
Psychonomic Society
Society for Neuroscience

Publications

Burgmans,. S., van Boxtel M.P.J, Gronenschild E.H.B.M., Vuurman, E.F.P.M., Hofman, P., Uylings, H.B.M., Jolles, J, &  Raz, N.  (2010) Multiple indicators of age-related differences in cerebral white matter and the modifying effects of hypertension. NeuroImage, in press.

Walhovd, K.B., Westlye, L.T., Amlien, I., Espeseth, T., Reinvang, I. Raz, N., Agartz, I., Salat, D.H., Greve, D.N., Fischl, B., Dale, A.M., & Fjell, A.M. (2010).Consistent neuroanatomical age-related volume differences across multiple samples. Neurobiology of Aging, in press.

Raz, N., Dahle, C.L., Rodrigue, KM , Kennedy, KM, Land, S. (2010). Effects of age, genes, and pulse pressure on executive functions in healthy adults. Neurobiology of Aging, in press.

Ghisletta, P., Kennedy, K.M., Rodrigue, K.M. Lindenberger, U., & Raz, N. Adult age differences and the role of cognitive resources in perceptual-motor skill acquisition: Application of a multilevel negative exponential model. Journal of Gerontology: Psychological Sciences, in press.

Raz, N., & Lindenberger, U. The news of cognitive cure for age-related brain shrinkage is premature. A comment on Burgmans et al., Neuropsychology, in press.

Taconnat, L., Baudouin, A., Fay, S., Raz, N.,Bouazzaoui, B., El-Hage1, W., Isingrini, M.& Ergis, A.M Episodic memory and organizational strategy in free recall in unipolar depression: the role of cognitive support and executive functions. Journal of Experimental and Clinical Neuropsychology, in press.

Kennedy KM, Rodrigue KM, Land SJ & Raz N (2009) BDNF val66met polymorphism influences age differences in microstructure of the corpus callosum. Frontiers in Human Neuroscience doi:10.3389/neuro.09.019.2009.

Kennedy, KM. & Raz, N. (2009).  Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk. Brain Research, 1297, 41-56.

Fjell, A.M., Westlye, L.T., Amlien, I., Espeseth, T., Reinvang, I. Raz, N., Agartz, I., Salat, D.H., Greve, D.N., Fischl, B., Dale, A.M., & Walhovd, K.B.  (2009). High consistency of regional cortical thinning in aging across multiple samples. Cerebral Cortex, 19, 2001-2012

Fjell, A.M., Westlye, L.T., Amlien, I., Espeseth, T., Reinvang, I. Raz, N., Agartz, I., Salat, D.H., Greve, D.N., Fischl, B., Dale, A.M., & Walhovd, K.B. (2009). Minute effects of sex on the aging brain: a multi-sample MRI-study of healthy aging and Alzheimer’s disease. Journal of Neuroscience, 29, 8774-8783.

Westlye L.T, Walhovd, K.B., Dale,  AM., Espeseth, T., Reinvang, I., Raz, N., Agartz, I., Greve, D., Fischl, B., & Fjell, A.M. (2009). Increased sensitivity to effects of normal aging and Alzheimer's disease on cortical thickness by adjustment for local variability in gray/white contrast: A multi-sample MRI study. NeuroImage, 47, 1545-1557. Epub 2009 Jun 6.

Raz, N. (2009). Decline and compensation in aging brain and cognition: Promises and constraints. Neuropsychology Review,19, 411-415.

Raz, N, Rodrigue, K.M., Kennedy, K.M., & Land, S. (2009). Genetic and vascular modifiers of age-sensitive cognitive skills: Effects of COMT, BDNF, ApoE and hypertension. Neuropsychology. 23, 105-116.

Deshmukh A, Rodrigue KM, Kennedy KM, Land S, Jacobs BS, & Raz N. (2009). Synergistic effects of the MTHFR C677T polymorphism and hypertension on spatial navigation. Biological Psychology, 80, 240-245. Epub ahead of prin2008 Nov 1.

Kennedy, K.M. & Raz, N. (2009) Aging white matter and cognition: Differential effects of regional variations in diffusion properties on memory, executive functions, and speed. Neuropsychologia, 47, 916–927.

 

Taconnat, L., Raz, N., Toczé, C., Bouazzaoui, B., Sauzéon, H., Fay, S., & Isingrini, M. (2009).Aging and organization strategies in free recall: the role of cognitive flexibility. The European Journal of Cognitive Psychology. 21, 347_365

Head, D., Kennedy, KM, Rodrigue, KM, & Raz, N. (2009). Age differences in perseveration: Cognitive and neuroanatomical mediators of performance on the Wisconsin Card Sorting Test. Neuropsychologia, 47, 1200-1203.

Kennedy, K.M., Hope, K., & Raz, N. (2009). Lifespan adult faces: Norms for age, familiarity, memorability, mood, and picture quality. Experimental Aging Research, 35: 268–275,

Dahle, C.L., Jacobs, B.S., & Raz, N. (2009). Aging, vascular risk and cognition: Blood glucose, pulse pressure, and cognitive performance in healthy adults. Psychology and Aging, 24, 154-162.

Rajah, M.N., Bastianetto, S.; Bromley-Brits, K., Cools, R., D'Esposito, M, Grady, C., Poirier, J., Quirion, R., Raz, N, Song, W., & Pruesnner, J. (2009). Biological changes associated with healthy versus pathological aging: A symposium review. Ageing Research Review, 8, 140-146.

Kennedy, K.M., Rodrigue, K.M., Head, D., Gunning-Dixon, F., & Raz, N. (2009). Neuroanatomical and cognitive mediators of age-related differences in perceptual priming and learning. Neuropsychology, 23, 475–491.

Kennedy KM, Rodrigue KM, Land SJ & Raz N (2009) BDNF val66met polymorphism influences age differences in microstructure of the corpus callosum. Frontiers in Human Neuroscience doi:10.3389/neuro.09.019.2009.

 

Fjell, A.M., Westlye, L.T., Amlien, I., Espeseth, T., Reinvang, I. Raz, N., Agartz, I., Salat, D.H., Greve, D.N., Fischl, B., Dale, A.M., & Walhovd, K.B.  (2009). High consistency of regional cortical thinning in aging across multiple samples. Cerebral Cortex, in press.

Fjell, A.M., Westlye, L.T., Amlien, I., Espeseth, T., Reinvang, I. Raz, N., Agartz, I., Salat, D.H., Greve, D.N., Fischl, B., Dale, A.M., & Walhovd, K.B. (2009). Minute effects of sex on the aging brain: a multi-sample MRI-study of healthy aging and Alzheimer’s disease. Journal of Neuroscience, in press.

Walhovd, K.B., Westlye, L.T., Amlien, I., Espeseth, T., Reinvang, I. Raz, N., Agartz, I., Salat, D.H., Greve, D.N., Fischl, B., Dale, A.M., & Fjell, A.M. (2009).Consistent neuroanatomical age-related volume differences across multiple samples. Neurobiology of Aging, in press.

Westlye L.T, Walhovd, K.B., Dale,  AM., Espeseth, T., Reinvang, I., Raz, N., Agartz, I., Greve, D., Fischl, B., & Fjell, A.M. Increased sensitivity to effects of normal aging and Alzheimer's disease on cortical thickness by adjustment for local variability in gray/white contrast: A multi-sample MRI study. NeuroImage, 2009 Jun 4. [Epub ahead of print]

Raz, N., Dahle, C.L., Rodrigue, KM , Kennedy, KM, Land, S. Effects of age, genes, and pulse pressure on executive functions in healthy adults. Neurobiology of Aging, in press.

Kennedy, KM. & Raz, N.  Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk. Brain Research, in press.

Raz, N, Rodrigue, K.M., Kennedy, K.M., & Land, S. (2009). Genetic and vascular modifiers of age-sensitive cognitive skills: Effects of COMT, BDNF, ApoE and hypertension. Neuropsychology. 23, 105-116.

Deshmukh A, Rodrigue KM, Kennedy KM, Land S, Jacobs BS, Raz N. (2009). Synergistic effects of the MTHFR C677T polymorphism and hypertension on spatial navigation. Biological Psychology, 80, 240-245. Epub ahead of prin2008 Nov 1.

Kennedy, K.M. & Raz, N. (2009) Aging white matter and cognition: Differential effects of regional variations in diffusion properties on memory, executive functions, and speed. Neuropsychologia, 47, 916–927.

 

Raz, N., Rodrigue, K. M. , & Haacke, E.M.  (2007). Brain aging and its modifiers: Insights from in vivo neuromorphometry and Susceptibility Weighted Imaging. Annals of New York Academy of Science, 1097, 84-93.

Raz, N., Rodrigue, K.M., Kennedy, K.M., & Acker, J.D. (2007). Vascular health and longitudinal changes in brain and cognition in middle-aged and older adults. Neuropsychology, 21, 149-157.

Kennedy, K.M., Partridge, T., & Raz, N. (2007). Age-related differences in acquisition of perceptual-motor skills: Working memory as a mediator. Aging, Neuropsychology, and Cognition, in press.

Raz, N., Lindenberger, U., Ghisletta, P., Rodrigue, K.M., Kennedy, K.M., & Acker, J.D. (2007). Neuroanatomical correlates of fluid intelligence in healthy adults and persons with vascular risk factors. Cerebral Cortex, 2007 Jul 5; [Epub ahead of print]

Raz, N, (2007). Which side of plasticity? A comment on Greenwood. Neuropsychology, 21, 676-677.

Kennedy, K.M., Hope, K., & Raz, N. Lifespan adult faces: Norms for age, familiarity, memorability, mood, and picture quality. Experimental Aging Research, in press

 

Thornton, W.J.L & Raz, N. (2006). Aging and the role of working memory resources in visuospatial attention. Aging, Neuropsychology, and Cognition, 13, 36–61.

Moffat SD, Kennedy KM, Rodrigue KM, Raz N. (2006). Extrahippocampal contributions to Age Differences in Human Spatial Navigation. Cerebral Cortex, Jul 20; [Epub ahead of print]

Raz N, Rodrigue KM (2006). Differential aging of the brain: Patterns, cognitive correlates and modifiers. Neuroscience and Biobehavioral Reviews, 30:730-748. Epub 2006 Aug 17.

 

Kennedy, K. M., Rodrigue, K. M., & Raz, N. (2006). Fragmented pictures revisited: Long-term changes in repetition priming, relation to skill learning, and the role of cognitive resources. Gerontology, 53, 148-158.

Erickson, KI, Colcombe, SJ, Raz, N., Korol, DL., Scalf, P., Webb, A., Cohen, NJ, McAuley, E., Kramer, AF., (2005). Selective sparing of brain tissue in postmenopausal women receiving hormone replacement therapy. Neurobiology of Aging, 26, 1205-1213.

Kennedy, KM, & Raz, N. (2005). Age, sex, and regional brain volumes predict perceptual-motor skill acquisition. Cortex, 41, 560-569.

Raz, N., Lindenberger, U., Rodrigue, K.M., Kennedy, K.M., Head, D. Williamson, A., Dahle, C., Gerstorf, D., & Acker, J.D. (2005). Regional brain changes in aging healthy adults: General trends, individual differences, and modifiers. Cerebral Cortex, 15, 1676-1689.

Rodrigue, K.M., Kennedy, KM, & Raz., N. (2005). Aging and longitudinal change in perceptual-motor skill acquisition in healthy adults. Journal of Gerontology: Psychological Sciences,60B, P174-181.

Raz, N., Rodrigue, KM, Kennedy, KM, & Acker, J.D. (2004). Hormone replacement therapy and age-related brain shrinkage: regional effects.

Raz, N., Gunning-Dixon, F., Head, D., Rodrigue, K., Williamson, A., Acker, J. (2004). Aging, sexual dimorphism, and hemispheric asymmetry of the cerebral cortex: Replicability of regional differences in volume. Neurobiology of Aging, 25,377-396.

Rodrigue, K. & Raz, N. (2004). Shrinkage of the entorhinal cortex over five year predicts memory performance in healthy adults. Journal of Neuroscience, 24, 956-963

Raz, N., Rodrigue, K., Head, D., Kennedy, K, Acker, J. (2004). Differential aging of the medial temporal lobe: A Study of a five-year change.

Raz, N., Rodrigue, K., Acker, J. (2003). Hypertension and the brain: Vulnerability of the prefrontal regions and executive functions. Behavioral Neuroscience, 17, 1169-1180.

Raz, N., Rodrigue, K., Kennedy, K., Head, D., Gunning-Dixon, F., Acker, J. (2003). Differential aging of the human straitum: Longitudinal evidence. American Journal of Neuroradiology, 24, 1849-1859.

Gunning-Dixon, F., & Raz, N. (2003). Neuroanatomical correlates of selected executive functions in middle-aged and older adults: A prospective MRI study. Neuropsychologia, 41,1929-1941.

Korman, M., Raz, N., Flash, T., & Karni, A. (2003). Multiple shifts in the representation of a motor sequence during the acquisition of skilled performance. Proceedings of the National Academy of Science USA, 100, 12492-12497.

Raz, N., Rodrigue, K., Kennedy, K., Dahle, C., Head, D., Acker, J. (2003). Differential age-related changes in the regional metencephalic volumes in humans: A five-year follow-up. Neuroscience Letters, 349, 163-166.

Colcombe S, Erickson KI, Raz, N., Webb AG, Cohen NJ, McAuley E, et al. (2003). Aerobic fitness reduces brain tissue loss in aging humans.

Head, D.,

NeuroReport, 15, 2531-2534. Neurology, 62, 433-439. Journal of Gerontology: Biological Sciences and Medical Sciences, 58A, 176-180.Raz, N., Gunning-Dixon, F., Williamson, A., & Acker, J.D. (2002). Age-related shrinkage of the prefrontal cortex is associated with executive, but not procedural aspects of cognitive performance. Psychology and Aging, 17, 72-84

Raz N. , Gunning-Dixon F., Head D., Williamson A., Acker J.D. (2001) Age and sex differences in the cerebellum and the ventral pons: a prospective MR study of healthy adults. AJNR Am J Neuroradiology, Jun;22(6):1161-1167

Thornton , A.E., Raz, N., & Tucker, K.A. (2001). Memory in multiple sclerosis: Contextual encoding deficits. Journal of the International Neuropsychological Society, in press.

Gunning-Dixon, F.M., & Raz, N. (2000). The cognitive correlates of white matter abnormalities in normal aging: A quantitative review.

Briggs, S.D. , Neuropsychology, 14, 224-232. Raz, N., & Marks, W. (1999).Age-related deficits in generation and manipulation of mental images: I. The role of sensorimotor speed and working memory. Psychology and Aging, 14,427-435.

Raz, N., Briggs, S.D. , Marks, W., & Acker, J.D. (1999).Age-related deficits in generation and manipulation of mental images: II. The role of dorsolateral prefrontal cortex. Psychology and Aging, 14, 436-445.

Raz, N., Williamson, A., Gunning-Dixon, F., Head, D., & Acker, J.D. (2000). Neuroanatomical and cognitive correlates of adult age differences in acquisition of a perceptual-motor skill. Microscopy Research and Technique, a special issue on Neuroimaging and Memory, 51, 85-93.

Gunning-Dixon, F.M., Head, D.P., McQuain, J.M., Acker, J.D., & Raz, N.(1998). Differential aging of the human striatum: A prospective MR study.

American Journal of Neuroradiology, 19, 1501-1507. Raz, N., Dixon , F.M., Head, D. P., Dupuis, J.H., & Acker, J.D. (1998). Neuroanatomical correlates of cognitive aging: Evidence from structural MRI. Neuropsychology, 12, 95-106.

Raz, N., Dupuis, J.H., Briggs, S.D. , McGavran, C., & Acker, J.D. (1998). Differential effects of age and sex on the cerebellar hemispheres and the vermis: A prospective MR study. American Journal of Neuroradiology, 19, 65-71.

Thornton, A.E. & Raz, N. (1997). Memory in multiple sclerosis: A quantitative review. Neuropsychology, 11, 357-366.

Moberg, P.A. & Raz, N.(1997).Aging and olfactory recognition memory: Effect of encoding strategies and cognitive abilities. International Journal of Neuroscience, 90, 277-292.

Raz, N., Gunning, F.M., Head, D., Dupuis, J.H., McQuain, J.M., Briggs, S.D., Thornton, A.E., Loken, W.J. & Acker, J.D. (1997). Selective aging of human cerebral cortex observed in vivo: Differential vulnerability of the prefrontal gray matter. Cerebral Cortex, 7, 268-282.


Books and Book Chapters

Raz, N. & Kennedy, K.M. (2009). A Systems Approach to Age-Related Change: Neuroanatomic changes, their modifiers, and cognitive correlates. In: W. Jagust, & M. D’Esposito. Imaging the Aging Brain. (Eds.) New York, NY: Oxford University Press, pp. 43-70.

Raz, N. & Nagel, I.E. (2007). Der Einfluss des Hirnalterungsprozesses auf die Kognition – eine Integration struktureller und funktioneller Forschungsergebnisse. In: J. Brandtstädter & U. Lindenberger (Eds.), Entwicklungspsychologie der Lebensspanne. Ein Lehrbuch. Stuttgart: Kohlhammer.

Raz, N. (2006). Societal factors in cognitive aging: One eye wide shut? In: Schaie, K. W. and Carstensen, L.L. (eds.) Social Structures, Aging, and Self-Regulation in the Elderly, New York, NY: Springer.

 

Raz, N. (July 2005) Ageing and the Brain. In: Encyclopedia of Life Sciences. John Wiley & Sons, Ltd: Chichester http://www.els.net/   [doi:10.1038/npg.els.0004063].

Raz, N. (2005).The aging brain observed in vivo: Differential changes and their modifiers. In R. Cabeza, L. Nyberg, & D. C. Park (Eds.), Cognitive Neuroscience of Aging: Linking Cognitive and Cerebral Aging. New York: Oxford University Press, pp.17-55.

Raz, N. (2004). The aging brain: Structural changes and their implications for cognitive aging. In Dixon , R. & Nilsson, L.G. (Eds.) New Frontiers in Cognitive Aging. New York: Ox Oxford University Press.

Raz, N. (Ed.) (1998). The Other Side of the Error Term: Aging and Development as Model Systems In Cognitive Neuroscience. Advances in Psychology series, v. 125. Amsterdam, The : Elsevier Science.

Raz, N. (2001). Cognitive aging. In: V. S. Ramachandran (Ed.) The Encyclopedia of the Human Brain. San Diego, CA : Academic Press

Raz, N. (2001). Ageing and the brain. In Encyclopedia of Life Sciences. London, : Macmillan Reference Ltd.

Raz, N. (2000). Aging of the brain and its impact on cognitive performance: Integration of structural and functional findings. In: F.I.M. Craik and T.A. Salthouse (Eds.) Handbook of Aging and Cognition - II. (Pp. 1-90). Mahwah, NJ : Erlbaum.

Raz, N. (1996). Neuroanatomy of aging brain: Evidence from structural MRI. In: Bigler, E.D. (ed.) Neuroimaging II: Clinical Applications, New York : Academic Press (pp.153-182).

Raz, N. (1994). Psychophysical measures of intelligence. In: Sternberg, R.J. (Ed.) Encyclopedia of Intelligence. New York : Macmillan.

Presentations

Rodrigue, KM.. Kennedy, KM, Head, D., Williamson, A. and Raz, N. Aging and long-term retention of a cognitive skill. Presented at the Annual Meeting of the Cognitive Neuroscience Society, April 2005, New York, NY.

Head, D., Gunning-Dixon, F., Williamson, A., Acker, JD., and Raz , N.  Neuroanatomical and cognitive correlates of age-related differences in mirror-reading skill acquisition. Presented at the Annual Meeting of the Cognitive Neuroscience Society, April 2005, New York, NY.

Kennedy, KM, Rodrigue, KM, and Raz, N. Age-related perceptual priming, but not perceptual learning is associated with visual cortex volume in healthy adults. Presented at the Annual Meeting of the Cognitive Neuroscience Society, April 2005, New York, NY.

Raz, N. Differential Aging of the brain: Patterns, cognitive correlates and modifiers. Presented at the conference on the Future of Cognitive Aging, May 20, 2005, State College, PA.

Raz, N., Rodrigue, K.M., Kennedy, K.M., Acker, J.D. Aging brain, health and fluid reasoning: A longitudinal study. Presented at the Annual Meeting of the Society for Neuroscience, November 13, 2005, Washington, DC.

Raz, N., Rodrigue, K.M. Kennedy, K.M., & Acker, J.D. The effects of age and vascular health on brain and cognition: a longitudinal study. Presented at the Workshop on Sensory and Cognitive Impairments in Aging and Neurodegenerative Diseases, Segovia, Spain, December, 18-20, 2005

Rodrigue, KM, Kennedy K.M., Haacke, E. M., Raz, N. Differential effects of age and hypertension on hemodynamic parameters of the brain. Presented at Cognitive Aging Conference, Atlanta, GA April 23, 2006.

Raz, N., Lindenberger, U, Ghisletta, P., Rodrigue, K. M, Kennedy, KM, & Acker, JD. Regional changes in the aging brain and their implications for cognition. Presented at Cognitive Aging Conference, Atlanta, GA April 23, 2006.

Moffat, S.D., Kennedy, K.M., Rodrigue, K.M. and Raz, N. Age-differences in human spatial navigation: extra-hippocampal contributions. Presented at Cognitive Aging Conference, Atlanta, GA April 23, 2006.

Raz, N. Brain Aging and its Modifiers: Insights from in vivo Neuromorphometry. Presented at the New York Academy of Science – American Federation for Aging Research Symposium, New York, NY May 17, 2006

Rodrigue, K.M., Kennedy, K.M., Haacke, E.M., and Raz, N. Differential effects of age and hypertension on hemodynamic parameters of the brain. Presented at the Annual Meeting of the Organization for Human Brian Mapping at Florence, Italy, June 11, 2006

Raz, N., Lindenberger, U., Ghisletta, P., Rodrigue, K.M., Kennedy, K.M., Acker, J.D., Regional Changes in the Aging Brain, Vascular Health, and Implications for Cognition.  Presented at the Annual Meeting of the Organization for Human Brian Mapping at Florence, Italy, June 11, 2006.

Kennedy, K.M., Erickson, K.I., Rodrigue, K.M., Webb, M. Colcombe, SJ., Kramer, A.F., Raz, N. Age-Related Differences in Regional Brain Volumes: A Comparison of Manual Volumetry and Voxel Based Morphometry. Presented at the Annual Meeting of the Organization for Human Brian Mapping at Florence, Italy, June 13, 2006.

Raz, N. Aging of the Brain: Neurobiology and Imaging. Plenary talk, presented at the Alzheimer’s Imaging Consortium Annual Meeting, Madrid, Spain, July 15, 2006.

Kennedy, K.M, Erickson, K.I., Rodrigue, KM., Voss, M., Kramer, A.F., Raz, N. Age-Related Differences in Regional Brain Volumes: Manual Volumetry vs. Voxel-Based Morphometry. Presented at Cognitive Neuroscience Society annual meeting, New York, NY, May 6, 2007.

Raz, N. Structural changes and cognitive consequences: Studies of brain aging and its modifiers. Presented at the Longevity Consortium Symposium, Santa Fe, NM, May 17, 2007.

Raz, N. Differential Brain Aging and its Modifiers: Volumetric Findings. Presented at the Neuroradiology Education and Research (NER) Foundation Symposium 2007:  The Aging Brain, Annual Meeting of American Neuroradiological Society, Chicago, IL, June 9, 2007.

Raz, N., Rodrigue, K.M., Kennedy, K.M., Land, S. Selected single-nucleotide polymorphisms and cognitive performance: Differential associations. Presented at the Annual Meeting of the Society for Neuroscience, San Diego, CA, November 7, 2007.

Kennedy, K.M, and Raz, N. Regional white matter integrity and cognitive performance: the effects of age and vascular risk factors. Presented at the Annual Meeting of the Society for Neuroscience, San Diego, CA, November 4, 2007.

Rodrigue K. M. Haacke, E.M., & Raz N. Differential effects of age and hypertension on regional brain structure and function assessed by regional T2* relaxometry and volumetry. Presented at the Annual Meeting of the Society for Neuroscience, San Diego, CA, November 7, 2007

Dahle C.L, Jacobs B.S., & Raz, N. Vascular Risk Factors and Cognitive Performance in Healthy Adults. Presented at Cognitive Aging Conference, Atlanta, GA  April 12, 2008.

Bender, A., Kennedy, K.M., & Raz, N. Age-related differences in item and association memory for names and faces. Presented at Cognitive Aging Conference, Atlanta, GA April 12, 2008

Kennedy, K.M., & Raz, N. Age and vascular related effects on regional white matter integrity and its effect on cognition. Presented at Cognitive Aging Conference, Atlanta, GA April 10, 2008

Raz, N., Rodrigue, K.M., Kennedy, K.M., & Land, S. Genetic and Vascular Modifiers of Age-Sensitive Cognitive Skills. Presented at Cognitive Aging Conference, Atlanta, GA April 11, 2008

Rodrigue, K. M. Haacke, E. M. Raz. N.  Differential Effects of Age and Hypertension on Regional Brain Anatomy and Physiology Assessed by Regional T2* Relaxometry and Volumetry. Presented at the annual meeting of the International Society for Magnetic Resonance in Medicine, Toronto, Ontario, Canada, May 8, 2008

Raz, N, Jacobs, BS, Rodrigue, KM., Kennedy, KM, Dahle, CL, Land, S. Effects of high-normal fasting glucose blood levels and BDNF val66met polymorphism on associative memory in healthy adults.  Presented at the New York Academy of Science conference on Integrative Physiology, May 15, 2008

Raz, N., Dahle, C.D., Rodrigue, K.M., Kennedy, K.M., Land, S., Jacobs, B.S., BDNF Val66Met polymorphism modifies the relationship between fasting blood glucose and memory in healthy adults: towards epigenetics of memory.

Dahle, C.L. and Raz, N. Insertion-deletion polymorphism of the angiotensin-converting-enzyme (ACE) gene affects working memory in healthy adults. To be presented at the Society for Neuroscience annual meeting, Washington, DC, November 19, 2008

Deshmukh, AB., Raz, N., Kennedy, K.M., Rodrigue, K.M., Moffat, S., Jacobs, B.S., Land, S.  Role of 5, 10-Methylenetetrahydrofolate reductase C677T polymorphism and hypertension in navigation ability in healthy adults. To be presented at the Society for Neuroscience annual meeting, Washington, DC, November 19, 2008

Kennedy, K. M., Rodrigue, K. M., Land, S., & Raz, N  Dissociation between aging of anterior and posterior corpus callosum microstructure depends on BDNFval66met polymorphism. To be presented at the Society for Neuroscience annual meeting, Washington, DC, November 19, 2008

Bender, A.R., Kennedy, K.M., & Raz, N. Age-related differences in item and association memory for word pairs.  To be presented at eh Meeting of Gerontological Society of America, November 2008.

 

Raz, N. Aging of Brain and Cognition: The Role of Vascular and Genetic Modifiers. Invited presentation at XXIIème Journées de Group de Recherche sur la Maladie d’Alzheimer (GRAL), Marseille, France, January 23, 2009.

Kennedy, K. M., & Raz, N Genetic marker of pro-inflammatory response is associated with age-dependent reduction in white matter integrity. Presented at the Cognitive Neuroscience Society meeting. San Francisco, CA March 22, 2009.

Kennedy, K.M., & Raz, N. Dissociation between Aging of Anterior and Posterior Corpus Callosum Microstructure Depends on Genotype. Presented at International Society for Magnetic Resonance in  Medicine Annual meeting, Honolulu, HI, April, 2009.

Benson R.R., Gattu R., Raz, N., Kennedy, K., Kou, Z., Haacke, E.M. Variation in DTI-FA as a Function of Age and Brain Region: Setting the Stage for Mild TBI. Presented at International Society for Magnetic Resonance in Medicine Annual meeting, Honolulu, HI, April, 2009.

Bender, A.R., & Raz, N. Hippocampal volume at baseline predicts memory for associations at  a two-year follow-up in healthy adults. Presented at the Society for Neuroscience annual meeting. Chicago, IL, October 18, 2009.

Burgmans,. S., van Boxtel M.P.J, Gronenschild E.H.B.M., Vuurman, E.F.P.M., Hofman, P., Uylings, H.B.M., Jolles, J, &  Raz, N. Multiple indicators of age-related differences in cerebral white matter and the modifying effects of hypertension. Presented at the Society for Neuroscience annual meeting. Chicago, IL, October 20, 2009.

Yang, Y.Q., Rodrigue, K.M., & Raz, N. White matter deterioration in less than three years observed in healthy adults. Presented at the Society for Neuroscience annual meeting. Chicago, IL, October 20, 2009.

Raz, N., Kennedy, K.M., & Rodrigue K.M.  Differential shrinkage of cerebral cortical regions in healthy adults. Presented at the Society for Neuroscience annual meeting. Chicago, IL, October 21, 2009.