Wayne State University

Aim Higher

Ana Marie Daugherty

Photo for Ana Marie Daugherty
Office Location
212 Knapp Bldg
Office Phone
313-664-2649
Bio Sketch

Ana is currently a postdoctoral research fellow in the Cognitive Neuroscience of Aging Laboratory at the Institute of Gerontology, Wayne State University. 

Research Focus

Her primary research interest is in the role of brain iron accumulation in aging.  Using multimodal imaging techniques (e.g., T2* and SWI phase) in healthy lifespan samples, she measures iron content in several regions of the brain, and models the relation between brain iron content, regional volumes, cognitive functions, and cardiovascular risk factors.  Her dissertation was a large-scale longitudinal study of these factors, employing structural equation modeling to estimate latent change and individual differences therein.

Although her primary interest is in healthy aging, she has expanded her research to include the entire lifespan, ages 8-90 years.  Using a specialized high-resolution sequence, she manually measures hippocampal subfield volumes in children and adults.  With a lifespan approach, she models non-linear age differences in hippocampal subfield volumes and correlates age-related differences in volume with the development and decline in cognitive functions. 

Education
Year Degree Institution
     
 2011-2014  PhD, Behavioral & Cognitive Neuroscience (Psychology)  Wayne State University, Detroit, MI
     
 2008-2011  MA, Behavioral & Cognitive Neusocience (Psychology)  Wayne State University, Detroit, MI
     
 2003-2007  BS, Neuroscience & 
 Experimental Psychology
 Westmont College, Santa Barbara, CA

 

 

 

 

 

Training
  • Advanced multivariate and non-linear statistics, including structural equation modeling, longitudinal modeling, and hierarchical linear modeling
  • Research methods and practice in ongoing longitudinal study of aging
  • Technical neuroanatomical demarcation and measurement from MRI on T1-weighted, susceptibility-weighted, T2*, and T2-weighted FLAIR images
  • Software knowledge of SPSS, Systat, Sigma Plot, M+, HLM, LISREL, DSTAT, Analyze, SPIN, and Unreal Tournament 2003
  • Design and implementation of virtual environments in Unreal Tournament 2003
  • Administration of diverse cognitive measures
  • Theoretical fundamentals and safety of MRI
Grants
   
Blue Cross Blue Shield of MichiganGrant # 1893.SAP   (Daugherty)$3000
09/01/2012-03/31/2014The Role of Brain Iron Accumulation in Brain and Cognitive Decline (Dissertation)
Association for Gerontology in Higher EducationCareers in Aging Proposal  (Daugherty)$200
03/2012Funded proposal for a "Careers in Aging" seminar at Wayne State University

 

Professional Service
  • IOG Grad. Student Org. President, May 2011-May 2012
  • Behav. and Cog. Neuroscience Student representative, Feb. 2011-May 2012
  • Student representative of IOG for Assoc. for Gerontology in Higher Education, 2009-present
  • Co-chair of Careers in Aging event committee, 2011-2012
  • Chair of Lifespan Development Brown Bag committee, 2011-2012
  • Behav. and Cog. Neuroscience Faculty search committee, 2011-2012
  • IOG Grad. Student Org. Vice President, May 2010-Apr 2011
  • Organization of lifespan alliance student and faculty forum for statistical methods, Jan. 2011-May 2012
  • Organization of undergraduate Careers in Aging Event, April, 13, 2011
  • Organization of Meals-on-Wheels fundraiser with The Senior Alliance, Winter 2009, Spring 2010, Spring 2011
  • Participation in annual Brain-Bee, 2009
  • Student Neurosci. Society Brain Day planning, 2009
Professional Associations
  • Society of Human Brain Mapping, Student Member, 2014
  • Cognitive Neuroscience Society, Student Member, 2013-present
  • Gerontological Society of America, Student Member, 2009-present
  • Society for Neuroscience, Student Member, 2010-present
  • American Psychology Association, Student Affiliate, 2011-present
Honors and Awards
  • Gwen Hussa Shafer Memorial Fund Travel Award, May 2014
  • Institute of Gerontology Graduate Student Presenter, 1st Place, Jan 2014
  • Graduate Psychology Poster Award, 1st Place, Nov 2013
  • Elizabeth Olson Memorial Paper Award, May 2013
  • Julie A. Thomas Memorial Research Award, Mar 2013; Mar 2014
  • Graduate School Student Poster Presenter, 3rd Place, Mar 2013; Mar 2014
  • Steven A. Lewis Memorial Research Award, Apr 2012
  • Institute of Gerontolgoy Graduate Student Presenter, 3rd Place, Oct 2011
  • Institute of Gerontology Student Presenter Travel Award, Feb 2010; Feb 2011; Oct 2011; Oct 2012; Nov 2013; Feb 2014
  • Dean of Students Presenter Travel Award, Feb 2010, Feb 2011
Publications

Manuscripts  [PubMed Search for Abstracts]

Daugherty AM, Haacke EM, Raz N. In press. Striatal iron content predicts its shrinkage and changes in working memory after two years in healthy adults.

Daugherty AM, Bender AR, Yuan P, Raz N. 2015. Changes in search path complexity and length during learning of a virtual water maze: Age differences and differential associations with hippocampal subfields volumes. Cer Cor. [Epub ahead of print]. doi: 10.1093/cercor/bhv061

Daugherty AM, Ofen, N. 2015. That’s a good one! The role of metamemory belief in strategy efficacy during memory development. J Exptl Child Psych. 136: 17-29. doi: 10.1016/j.jecp.2015.02.008

Daugherty AM, Yu Q, Flinn R, Ofen N. 2015. A reliable and valid method for manual demarcation of hippocampus head, body and tail. Int. J Child Dev. 41: 115-22. doi: 10.1016/j.ijdevneu.2015.02.001

Yushkevich P, Amaral RS, Augustinack JC, Bender AR, Bernstein JD, Boccardi M, Bocchetta M, Burggren AC, Carr VA, Chakravarty MM, Chetelat G, Daugherty AM … Zenieh MM. 2014. Quantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal cortical subregions in in vivo MRI: Towards developing a harmonized segmentation protocol. NeuroImage. 111: 526-541. doi: 10.1016/j.neuroimage.2015.01.004

Persson N, Ghisletta P, Dahle CL, Bender AR, Yang Y, Yuan P, Daugherty AM, Raz N. 2014. Regional brain shrinkage over two years: Individual differences and effects of pro-inflammatory genetic polymorphisms. NeuroImage.103: 334-48. doi: 10.1016/j.neuroimage.2014.09.042

Sethi S, Utriainen D, Daugherty AM, Feng W, Hewett JJ, Raz N, Haacke EM. 2014. Jugular venous flow abnormalities in multiple sclerosis patients compared to normal controls. J Neuroimaging. [Epub ahead of print]. doi: 10.1111/jon.12183

Raz N, Daugherty AM, Bender AR, Dahle CL, Land S. 2014. Volume of the hippocampal subfields in healthy adults: Differential associations with age and a pro-inflammatory genetic variant. Brain Struct Funct. [Epub ahead of print].

Daugherty AM, Yuan P, Dahle CL, Bender AR, Yang Y, Raz N. 2014. Path complexity in virtual water maze navigation: Differential associations with age, sex, and regional brain volume. Cer Cor. [Epub ahead of print].

Adamo DE, Daugherty AM, Raz N. 2013. Brain iron content and grasp force-matching ability in older women. Brain Imag Behav. [Epub ahead of print].

Yuan P, Daugherty AM, Raz N. 2013. Turning bias in virtual navigation: Age-related differences and neuroanatomical correlates. Biol Psychol. 96C: 8-19. doi: 10.1016/j.biopsycho.2013.10.009

Bender AR, Daugherty AM, Raz N. 2013. Vascular risk moderates associations between hippocampal subfield volumes and memory. J Cog Neuro. 25(1): 1851-1862. doi: 10.1162/jcon_a_00435.

Daugherty A, Raz N. 2013. Age-related differences in iron content of subcortical nuclei observed in vivo: A meta-analysis. NeuroImage. 70: 113-121. doi:10.1016/j.neuroimage.2012.12.040.

 

Rodrigue KM, Daugherty AM, Haacke EM, Raz N. 2012. The role of hippocampal iron content and hippocampal volume in age-related differences in memory. Cer Cor. 23(7): 1533-41. doi: 10.1093/cercor/bhs139.

 

Selected Abstracts (past 3 years)

Daugherty AM, Raz N. 11/2014. Longitudinal iron accumulation is associated with regional brain shrinkage. Selected nanosymposium oral presentation at Society for Neuroscience Annual Conference.

Daugherty AM, Bender AR, Tang L, Raz N, Ofen N. 06/2014. Differential age-related decrease in hippocampal subfield volume from childhood to late adulthood. Poster presentation at Organization for Human Brain Mapping Annual Meeting.

Daugherty AM, Raz N. 04/2014. Longitudinal changes in spatial navigation performance across the adult lifespan. Poster presentation at Cognitive Aging Conference Biennial Meeting.

Daugherty AM, Yuan P, Dahle C, Bender AR, Yang Y, Raz N. 04/2014. Path complexity in virtual water maze navigation: differential associations with age, sex, and regional brain volume. Poster presentation at Cognitive Neuroscience Society Annual Meeting.

Daugherty AM, Ofen N. 11/2013. Developmental differences in hippocampal dentate gyrus account for improvement in associative memory. Poster presentation at Society for Neuroscience Annual Conference.

Raz N, Daugherty AM, Bender AR. 11/2013.Hippocampal volume in healthy adults: Age Differences and the Effects of Genetic and Physiological Pro-Inflammatory Markers. Poster presentation at Society for Neuroscience Annual Conference.

Adamo DE, Daugherty AM, Raz N. 07/2013. Increased iron content in the basal ganglia is associated with grasp-force matching. Progress in Motor Control IX.

Bender AR, Daugherty AM, Raz N. 04/2013. Magnitude of practice effects in associative memory is related to the volume of CA3/4-Dentate gyrus in healthy middle-aged and older adults. Poster at Cognitive Neuroscience Society Conference.

Daugherty AM, Bender AR, Raz N. 10/2012. Human navigation deficit is associated with hippocampal subfield volume. Poster at Society for Neuroscience Annual Meeting.

Bender AR, Daugherty AM, Raz N. 03/2012. Associations between age, hippocampal subfield volumes and episodic memory are modified by vascular risk. Poster presentation at biannual Cognitive Aging Conference.

Daugherty AM, Raz N. 11/2011. Age-related differences in spatial navigation are mediated by increased iron presence in the basal ganglia. Poster presentation at Society for Neuroscience Annual Conference.

 

Daugherty AM, Raz N. 02/2011. In vivo quantification of iron in healthy aging: Comparison of methods. Poster presentation at the Dallas Aging and Cognition Conference.

Teaching Experience

INSTRUCTOR OF RECORD             

2010                               Psychology Department, Wayne State University          Detroit, MI

Undergraduate Course: Brain and Behavior, PSY 3120

Instructor, Independent Lecture; 26 students

 

2008-2009                      Psychology Department, Wayne State University          Detroit, MI

Undergraduate Course: Introductory Psychology, PSY 1010

Instructor, Lecture and Laboratory Course; 2 semesters, 42 & 63 students per semester

 
INVITED GUEST LECTURES

2014                               Psychology Department, Wayne State University          Detroit, MI

Graduate Course: Cognitive Neuroscience, PSY 8720

Guest lecture: Spatial Navigation Processes and Neural Correlates

 

2012-2014             Eugene Applebaum College of Pharmacy & Health Sciences Detroit, MI

Graduate Course: Physical Therapy Rehabilitation, PT 7320

Guest lecture: Cognitive Aging and Dementia

 

2013                                Institute of Gerontology, Wayne State University          Detroit, MI

Cognitive and Brain Development Laboratory

Guest lectures: Multiple Regression; Mediation Analyses; Statistics for Small Samples

 

2012                         Merrill Palmer Skillman Institute, Wayne State University    Detroit, MI

Social Cognitive Affective Neuroscience Laboratory

Guest lecture: The Two Phases of Iron across the Lifespan

 

LECTURES CERTIFIED FOR CONTINUING EDUCATION UNITS

Memory Function As We Age                                                       Certified CE, 1.5 hours

      Certified by National Nursing and Michigan Social Work Associations

12/12/2013, Canton Waltonwood; 12/5/2013, Lakeside Waltonwood.

 

Biological and Lifestyle Factors that Affect Cognition.                  Certified CE, 1.5 hours

Certified by National Nursing and Michigan Social Work Associations.

      12/5/2012, Canton Waltonwood; 10/18/2012, Lakeside Waltonwood.

 

SELECTED COMMUNITY TALKS

Healthy Habits for Memory. 04/26/2014. Healthy Black Elders. Detroit, MI.

I Can’t Remember…Can You? 02/21/2014. Senior Outreach Center, Grosse Pointe Farms, MI.

Keeping the Memories Golden. 6/06/2013. St. Fabien’s Catholic Parish Elders. Farmington, MI.

Thanks for the Memories. 3/21/2013. Art of Aging Conference, Institute of Gerontology.

Why Can’t I Remember Like I Used To? 08/14/2012. Michigan Association of Retired School Personnel, Farmington Hills, MI.

Antioxidants, Brain Health and Cognitive Function. 04/24/2012. The City of Bloomfield Hills.

Cognitive Abilities as We Age and the Effects of Antioxidants on Brain Health. 04/19/2012. Brighthouse, Grosse Pointe Memorial, Grosse Pointe Farms.

I Can’t Remember…Can You? 03/13/2012. Waltonwood Retirement Comm., Rochester Hills, MI.

Promoting Healthy Cognition in the Golden Years. 02/04/2012. Henry Ford Hospital, Detroit, MI.

Presentations

Talks Certified for Professional Continuing Education Units

Memory Function As We Age.  Certified CE, 1.5 hours

        National Nursing and Michigan Social Work. 2/12/2013, Canton Waltonwood; 12/5/2013, Lakeside Waltonwood.

Biological and Lifestyle Factors that Affect Cognition.  Certified CE, 1.5 hours.

        National Nursing and Michigan Social Work. 12/5/2012, Canton Waltonwood; 10/18/2012, Lakeside Waltonwood.

 

 Selected Invited Talks

Keeping the Memories Golden.  6/06/2013.  St. Fabien's Catholic Parish Elder Group. Farmington, MI.

Thanks for the Memories.  3/21/2013. Art of Aging Conference, Institute of Gerontology.

Why Can't I Remember Like I Used To?  08/14/2012.  Michigan Association of Retired School Personnel, Farmington Hills, MI.

Antioxidants, Brain Health and Cognitive Function.  04/24/2012.  The City of Bloomfield Hills.

Cognitive Abilities as We Age and the Effects of Antioxidants on Brain Health.  04/19/2012.  Brighthouse, Grosse Pointe Memorial, Grosse Pointe Farms.

Promoting Healthy Cognition in the Golden Years.  02/04/2012.  Henry Ford Hospital, Church of Christ, Ladies Group.

The Two Phases of Iron across the Lifespan.  01/31/2012.  Social Cognitive Affective Neuroscience Lab, Merrill-Palmer Institute, Wayne State Univ.