Wayne State University

Aim Higher

Naftali Raz

Photo for Naftali Raz
Director of Lifespan Cognitive Neuroscience
Office Location
226 Knapp
Office Phone
313-664-2617
Bio Sketch

Dr. Raz completed his undergraduate studies at Hebrew University in Jerusalem, Israel, in 1979.  He was trained in psychology and human neuroscience at the University of Texas at Austin, and received his Ph.D. in 1985. Dr. Raz's research focuses on the neural correlates and modifiers of cognitive aging. His research has been continuously supported since 1993 by the National Institute on Aging. 

see our lab site for further details: http://agingbrain.wayne.edu/

Research Focus

The main themes in the current studies in Dr. Raz's lab are:

Differential aging of brain structure
The emphasis is on longitudinal approach to study of change and variability in the rates of change in regional brain volumes as well as regional integrity of the cerebite matter. The results of our previous studies (cross sectional comparisons and longitudinal follow-up) indicate that not all brain components age at the same rate. Association cortices, the caudate nucleus, the hippocampus and the cerebellum show steeper declines than the visual cortex, the entorhinal cortex and the pons. We are trying to identify the antecedents of change and the modifiers of the age trajectories of structural brain declines.


Cognitive consequences of structural brain aging
Although structural changes may be separated by cognitive declines by a long time period, some links between smaller regional volumes or faster longitudinal declines of brain regions and poorer performance on cognitive tasks have been noted. For example, we found that smaller prefrontal volumes are associated with greater difficulty to abandon previously reinforced but currently maladaptive cognitive strategy (Raz et al., 1998; Gunning-Dixon & Raz, 2003). Smaller putamen and cerebellar hemispheres are linked to poorer performance on perceptual-motor task (Raz et al., 2000), and the rate of shrinkage in usually stable entorhinal cortex is associated with reduced memory performance (Rodrigue & Raz, 2006).


Modifiers of brain aging:

  • Negative modifiers
    Hypertension, even when treated and reasonably well controlled, may still exert negative influence on the brain. We observed, however, that those negative effects are limited to the executive functions and the regions of their brain substrate - the anterior part of the frontal lobes (Raz et al, 2003). Sometimes, removal of mildly hypertensive subjects from a sample reduces age-related differences. We are currently attempting to replicate these findings and to examine possible mediators of the effects of mild hypertension on brain and cognition.
     
  • Positive modifiers
    Exercise is known to alleviate some of the effects of cardiovascular risk factors on many organs and systems, including the brain.
  • Genetic modifiers
    Multiple genes control complex cognitive functions and their brain substrates. Naturally occuring variants of specific genes affect production and expression of neurochemical compounds that modify neuroanatomy and behavior. Although those variants account for a small percentage of individual variation in brain and cognition, they are nonetheless important contributors to the emerging pattern of individual differences in human aging. For example, COMT Val158Met polymorphisms was found to affect executive functions, and in our sample, Met allele homozygotes performed better than Val allele carriers on several executive tests as well as more complex tests of fluid abilities. Selective executive functions are also affected by epsilon4 allele of ApoE polymorphisms known to increase the risk for Alzheimer's disease. We are currently examining the effects of polymorphisms associated with vascular risk and inflammatory processes as candidates for explaining age-related differences in brain and cognition. For instance, a variant in the gene that controls expression of Brain-Derived Neurotrophic Factor (BDNF) modifies memory performance in healthy adults. Notably, that variant (a met allele of the BDNF val66met polymorphism) may be more harmful to memory performance when it is combined with a modifiable vascular risk factor such as elevated (though nominally normal) blood glucose (Raz et al., 2008 Front Human Neurosci). Hence our interest in combined or synergistic influence of genetic and physiologicalvascular risk factors on brain and cognition in the context of aging. 

Areas of Expertise

 Aging of the brain and cognition

Courses Taught

 Undergraduate

  • Physiological Psychology

Graduate

  • Neuropathology and Behavior PSY7340
  • Cognitive Neuroscience
  • Functional Neuroanatomy PSY8060 (with Brain Dissection lab)  
Training Offered

In the Cognitive Neuroscience of Aging Laboratory, graduate students acquire a wide range of research skills. Their training includes computer-aided processing and analysis of MRI images, design and administration of cognitive and neuropsychological tests and statistical analysis. Our neuroimaging projects are conducted at the Wayne State University MRI Center and Departmenbt of Psychiatry and Behavioral Neuroscience in collaboration with E. Mark Haacke, Ph.D. http://www.mrc.wayne.edu/people/haackecv.pdf and Jeff Stanley http://psychiatry.med.wayne.edu/profile.php?id=45102

Current graduate students in the lab:

Alumni of the CNA Lab

  • Ivan J. Torres, Ph.D., 1993, Clinical Associate Professor, Department of Psychiatry, University of British Columbia, Vancouver, Canada,  ivan.torres@ubc.ca
  • Allen E. Thornton, Ph.D. 1995. Professor, Department of Psychology, Simon Fraser University, Burnaby, BC, Canada aethornt@sfu.ca web page:http://www.sfu.ca/psyc/faculty/thorntona/
  • Wendy Loken-Thorton, Ph.D. 1995. Associate Professor, Department of Psychology, Simon Fraser University, Burnaby, BC, Canada http://web.me.com/wthornto/Cognitive_Aging_Lab/Welcome.html
  • Faith Gunning-Dixon, Ph.D. 2000. Associate Professor, Department of Psychiatry, Cornell University Weill Medical College fgd2002@med.cornell.edu web: http://www.med.cornell.edu/research/fgdixon/biography.html
  • Denise Head, Ph.D. 2001. Associate Professor, Department of Psychology, Washington University.http://psychweb.wustl.edu/head
  • Karen Rodrigue, Ph.D  2007 Assistant Professor, Universityof Texas at Dallas http://vitallongevity.utdallas.edu/people/center-scientists/karen.html krodrigue@utdallas.edu
  • Kristen Kennedy , Ph.D. 2007 Assistant Professor,, University of Texas at Dallas, http://vitallongevity.utdallas.edu/people/center-scientists/kristen.html,  kristen.kennedy1@utdallas.edu
  • Cheryl L. Dahle, Ph.D., 2010 Wayne State University, Cognitive Neuroscience of Aging Lab, Project Manager -  ak0174@wayne.edu
  • Yiqin Yang, Ph.D., 2013 
  • Andrew Bender, Ph.D., 2014 Max Planck Institute for Human Development Postdoctoral Fellow -  bender@mpib-berlin.mpg.de
  • Peng Yuan, Ph.D., 2014, University of Michigan, Department of Kinesiology, Postdoctoral Fellow - yuanpeng@umich.edu
  • Ana M. Daugherty, Ph.D., 2014, University of Ilinois -Urbana, Beckman Postdoctoral Fellow - daughert@illinois.edu
Research Project Title
Neural Corelates and Modifiers of Cognitive Aging
Grants

Funding History

National Institute on Aging, grant 4R37AG011230 Neural Correlates and Modifiers of Cognitive Aging. Funding period: 7/1/10-6/30/16, total costs: $2,753,333, a MERIT award

National Institute on Aging, grant 2R37AG011230 Neural Correlates and Modifiers of Cognitive Aging. Funding period: 7/1/05-6/30/10, total costs: $2,090,389, a MERIT award

National Institute on Aging, grant R03-AG024630 "Hemodynamic predictors of brain and cognitive aging." $117,000 direct costs, funding period September 15, 2004 - June 30, 2007

National Institute on Aging, grant R01AG011230 Neural correlates of age related differences in memory. Funding period: 1999-2005, with no-cost extension

National Institute on Aging, grant R01AG011230 Neural correlates of age related differences in memory. Funding period: 1993-1999, with no-cost extension

Co-Investigator

National Institute of Aging grant R01-AG18008 "Aging, fitness and neurocognitive function" (A.F. Kramer, University of Illinois, PI) Funding period 3/1/02-2/28/05

Professional Associations

American Association for Advancement of Science
Cognitive Neuroscience Society
Memory Disorders Research Society
Society for Neuroscience

Publications

Selected publications. See ful llist in the CV attached.  .

Raz, N., Millman, D. & Sarpel, G. (1990). Cerebral correlates of cognitive aging: Grey-white matter differentiation in the medial temporal lobes, and fluid vs. crystallized abilities. Psychobiology, 18, 475-481.

21. Raz, N., Millman, D., & Moberg, P.J. (1990). On mechanisms of age-related differences in frequency discrimination with backward masking: Speed of processing versus stimulus persistence. Psychology and Aging, 5, 475-481.

Raz, N., Torres, I.J., Spencer, W.D., White, K., Acker, J.D. (1992). Age-related regional differences in cerebellar vermis observed in vivo. Archives of Neurology, 49, 412-416.

Raz, N., Torres, I.J., & Acker, J.D.  (1992). Age-related shrinkage of the mamillary bodies: Evidence from in vivo MRI. NeuroReport, 3, 713-716.

 

Raz, N., Torres, I.J., Spencer, W.D., Baertschi, J.C., Millman, D., Sarpel, G. (1993) Neuroanatomical correlates of age-sensitive and age-invariant cognitive abilities: An in vivo MRI investigation. Intelligence, 17, 407-421.

Raz, N., Torres, I.J., Spencer, W.D., & Acker, J.D. (1993) Pathoclysis in aging human cerebral cortex: Evidence from in vivo MRI morphometry. Psychobiology, 21, 151-160.

Raz, N., Torres, I., & Acker, J.D. (1995). Age, gender, and hemispheric differences in human striatum: A Quantitative review and new data from in vivo MRI morphometry. Neurobiology of Learning and Memory, 63, 133-142.

Raz, N., Torres, I.J., Briggs, S.D., Spencer, W.D., Thornton, A.E., Loken, W., Gunning, F.M., McQuain, J.D., Driesen, N.R., & Acker, J.D. (1995). Selective neuroanatomical abnormalities in Down's syndrome and their cognitive correlates: Evidence from MRI morphometry. Neurology, 45, 356-366.

Driesen, N.R. & Raz, N. (1995). Sex-, age-, and handedness-related differences in human corpus callosum observed in vivo. Psychobiology, 23, 240-247.

Spencer, W.D. & Raz, N. (1995). Differential age effects on memory for content and context: A meta-analysis. Psychology and Aging, 10, 527-539.

 Raz, N., Gunning, F.M., Head, D., Dupuis, J.H., McQuain, J.M., Briggs, S.D., Thornton, A.E., Loken, W.J. & Acker, J.D. (1997). Selective aging of human cerebral cortex observed in vivo: Differential vulnerability of the prefrontal gray matter. Cerebral Cortex, 7, 268-282.

Raz, N., Dupuis, J.H., Briggs, S.D., McGavran, C., & Acker, J.D. (1998). Differential effects of age and sex on the cerebellar hemispheres and the vermis: A prospective MR study. American Journal of Neuroradiology, 19, 65-71.

Raz, N., Dixon, F.M., Head, D. P., Dupuis, J.H., & Acker, J.D. (1998). Neuroanatomical correlates of cognitive aging: Evidence from structural MRI. Neuropsychology, 12, 95-106.

Gunning-Dixon, F.M., Head, D.P., McQuain, J.M., Acker, J.D., & Raz, N. (1998). Differential aging of the human striatum: A prospective MR study. American Journal of Neuroradiology, 19, 1501-1507.

Gunning-Dixon, F.M., & Raz, N.  (2000). The cognitive correlates of white matter abnormalities in normal aging: A quantitative review. Neuropsychology, 14, 224-232.

Raz, N., Williamson, A., Gunning-Dixon, F., Head, D., & Acker, J.D. (2000). Neuroanatomical and cognitive correlates of adult age differences in acquisition of a perceptual-motor skill.  Microscopy Research and Technique, a special issue on Neuroimaging and Memory, 51, 85-93.

           Raz, N., Gunning-Dixon, F., Head, D., Williamson, A.,.& Acker, J.D.  (2001). Age and sex differences in the cerebellum and the ventral pons: A Prospective MR study of healthy adults. American Journal of Neuroradiology, 22, 1161-1167.

           Head, D., Raz, N., Gunning-Dixon, F., Williamson, A., & Acker, J.D. (2002). Age-related shrinkage of the prefrontal cortex is associated with executive, but not procedural aspects of cognitive performance. Psychology and Aging, 17, 72-84.

Colcombe S, Erickson KI, Raz N, Webb AG, Cohen NJ, McAuley E, et al. (2003). Aerobic fitness reduces brain tissue loss in aging humans. Journal of Gerontology, A: Biological Sciences and Medical Sciences, 58A, 176–180.

Raz, N., Rodrigue, KM., Kennedy, KM, Dahle, C., Head, D, Acker, JD (2003). Differential age-related changes in the regional metencephalic volumes in humans: A five-year follow-up. Neuroscience Letters, 349, 163-166.

Raz, N, Rodrigue, KM, Kennedy, KM, Head, D., Gunning-Dixon, FM, Acker JD. (2003). Differential aging of the human striatum: Longitudinal evidence. American Journal of Neuroradiology, 24, 1849-1856.

Gunning-Dixon, F.M., & Raz, N. (2003). Neuroanatomical correlates of selected executive functions in middle-aged and older adults: A prospective MRI study. Neuropsychologia, 41, 1929-1941.

Raz, N., Rodrigue, KM, & Acker, JD (2003). Hypertension and the brain: Vulnerability of the prefrontal regions and executive functions. Behavioral Neuroscience, 17, 1169-1180.

 Raz, N., Gunning-Dixon, F., Head, D., Williamson, A., Rodrigue, K., Acker, J.D. (2004). Aging, sexual dimorphism, and hemispheric asymmetry of the cerebral cortex: Replicability of regional differences in volume. Neurobiology of Aging, 25, 377-396.

Rodrigue, KM & Raz, N. (2004). Shrinkage of the entorhinal cortex over five years predicts memory performance in healthy adults. The Journal of Neuroscience, 24, 956–963.

Raz, N., Rodrigue, KM, Kennedy, KM, & Acker, J.D. (2004). Hormone replacement therapy and age-related brain shrinkage: regional effects. NeuroReport, 15, 2531-2534.

 Raz, N., Lindenberger, U., Rodrigue, K.M., Kennedy, K.M., Head, D. Williamson, A., Dahle, C., Gerstorf, D., & Acker, J.D. (2005). Regional brain changes in aging healthy adults: General trends, individual differences, and modifiers. Cerebral Cortex, 15, 1676-1689.

Raz N, Rodrigue KM (2006). Differential aging of the brain: Patterns, cognitive correlates and modifiers. Neuroscience and Biobehavioral Reviews, 30:730-748. Epub 2006 Aug 17.

Moffat SD, Kennedy KM, Rodrigue KM, Raz N. (2007). Extrahippocampal contributions to age differences in human spatial navigation. Cerebral Cortex.17, 1274-1282. Epub 2006 Jul 20.

Raz, N., Rodrigue, K.M., Kennedy, K.M., & Acker, J.D. (2007). Vascular health and longitudinal changes in brain and cognition in middle-aged and older adults. Neuropsychology, 21, 149-157.

Raz, N, (2007). Which side of plasticity? A comment on Greenwood. Neuropsychology, 21, 676-677.

 Raz, N., Lindenberger, U., Ghisletta, P., Rodrigue, K.M., Kennedy, K.M., & Acker, J.D. (2008). Neuroanatomical correlates of fluid intelligence in healthy adults and persons with vascular risk factors. Cerebral Cortex, 18, 718-726; 2007 Jul 5; [Epub ahead of print]

Head, D., Rodrigue, K.M., Kennedy, K.M., & Raz, N. (2008). Neuroanatomical and cognitive mediators of age-related differences in episodic memory. Neuropsychology, 22:491-507.

Raz, N. Dahle, C., Rodrigue, K.M., Kennedy, KM, Land, S., & Jacobs, B.S. (2008). Brain-Derived Neurotrophic Factor Val66Met polymorphism, blood glucose, and memory in healthy adults: The synergy of genetic and vascular risks. Frontiers in Human Neuroscience, 2, article 12, 1-6.

Kennedy KM, Erickson KI, Rodrigue KM, Voss MW, Colcombe SJ, Kramer AF, Acker JD, Raz N.(2009). Age-related differences in regional brain volumes: a comparison of optimized voxel-based morphometry to manual volumetry. Neurobiology of Aging, 30, 1657-1676. Epub 2008 Feb 13. doi:10.1016/j.neurobiolaging.2007.12.020.

Raz, N, Rodrigue, K.M., Kennedy, K.M., & Land, S. (2009). Genetic and vascular modifiers of age-sensitive cognitive skills: Effects of COMT, BDNF, ApoE and hypertension. Neuropsychology. 23, 105-116.

Kennedy, K.M. & Raz, N. (2009) Aging white matter and cognition: Differential effects of regional variations in diffusion properties on memory, executive functions, and speed. Neuropsychologia, 47, 916–927.

Taconnat, L., Raz, N., Toczé, C., Bouazzaoui, B., Sauzéon, H., Fay, S., & Isingrini, M. (2009).Aging and organization strategies in free recall: the role of cognitive flexibility. The European Journal of Cognitive Psychology. 21, 347-365

Head, D., Kennedy, KM, Rodrigue, KM, & Raz, N. (2009). Age differences in perseveration: Cognitive and neuroanatomical mediators of performance on the Wisconsin Card Sorting Test. Neuropsychologia, 47, 1200-1203.

Kennedy, KM. & Raz, N.  (2009). Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk. Brain Research, 1297, 41-56.

Fjell AM, Westlye LT, Amlien I, Espeseth T, Reinvang I, Raz N, Agartz I, Salat DH, Greve DN, Fischl B, Dale AM, Walhovd KB. (2009). High consistency of regional cortical thinning in aging across multiple samples. Cerebral Cortex,19:2001-2012. Epub 2009 Jan 15.

Fjell, A.M., Westlye, L.T., Amlien, I., Espeseth, T., Reinvang, I. Raz, N., Agartz, I., Salat, D.H., Greve, D.N., Fischl, B., Dale, A.M., & Walhovd, K.B. (2009). Minute effects of sex on the aging brain: a multi-sample MRI-study of healthy aging and Alzheimer’s disease. Journal of Neuroscience, 29, 8774-8783

Westlye L.T, Walhovd, K.B., Dale, AM., Espeseth, T., Reinvang, I., Raz, N., Agartz, I., Greve, D., Fischl, B., & Fjell, A.M. (2009). Increased sensitivity to effects of normal aging and Alzheimer's disease on cortical thickness by adjustment for local variability in gray/white contrast: A multi-sample MRI study. NeuroImage, 47, 1545-1557. Epub 2009 Jun 6.

Burgmans, S., van Boxtel M.P.J, Gronenschild E.H.B.M., Vuurman, E.F.P.M., Hofman, P., Uylings, H.B.M., Jolles, J, &  Raz, N. (2010). Multiple indicators of age-related differences in cerebral white matter and the modifying effects of hypertension. NeuroImage, 49, 2083-2093, 2009 Oct 19. [Epub ahead of print].

Raz, N. & Lindenberger, U. (2010). News of cognitive cure for age-related brain shrinkage is premature: A comment on Burgmans et al. (2009).  Neuropsychology, 24, 255-257.

Raz, N., Ghisletta, P., Rodrigue, K.M., Kennedy, K.M., Lindenberger, U. (2010). Trajectories of brain aging in middle-aged and older adults: Regional and individual differences. NeuroImage, 51, 501-511, March 8, 2010. [Epub ahead of print].

Bender, A.R., Naveh-Benjamin, M., & Raz, N. (2010). Associative deficit in recognition memory in a lifespan sample of healthy adults. Psychology and Aging, 25, 940-948,

Raz, N., Dahle, C.L., Rodrigue, KM , Kennedy, KM, Land, S. (2011). Effects of age, genes, and pulse pressure on executive functions in healthy adults. Neurobiology of Aging, 32, 1124–1137, 2009, Jun 24. [Epub ahead of print].

Rodrigue, K.M., Haacke, E.M., Raz, N. (2011). Differential effects of age and hypertension on regional brain volumes and iron. NeuroImage, 54, 750-759, 2010 Oct 19. [Epub ahead of print].

Burgmans., S., Gronenschild, E.H.B.M.,, Fandakova, Y., Shing, Y.L., van Boxtel, M.P.J. Vuurman,  E.F.P.M. Uylings, H.B.M., Jolles, J. Raz, N., (2011). Age differences in speed of processing are partially mediated by differences in axonal integrity. NeuroImage, 55, 1287–1297, 2011 Jan 11. [Epub ahead of print]

Raz, N., Yang, Y.Q., Rodrigue, K.M., Kennedy, K.M., Lindenberger, U., Ghisletta, P., (2011). White matter deterioration in 15 months: Latent growth curve models in healthy adults. Neurobiology of Aging, 2010 Dec 29. [Epub ahead of print]

Walhovd, K.B., Westlye, L.T., Amlien, I., Espeseth, T., Reinvang, I. Raz, N., Agartz, I., Salat, D.H., Greve, D.N., Fischl, B., Dale, A.M., & Fjell, A.M. (2011). Consistent neuroanatomical age-related volume differences across multiple samples. Neurobiology of Aging , 32, 916-932, 2009, Jun 29. [Epub ahead of print].

Raz, N. & Lindenberger, U. (2011). Only time will tell: Cross-sectional studies offer no solution to the Age-Brain-Cognition triangle—Comment on Salthouse (2011). Psychological Bulletin, 137, 790–795.

Shing, YL, Rodrigue, KM., Kennedy, KM., Fandakova, Y., Bodammer, Werkle-Bergner. M, Lindenberger, U., Raz, N. (2011). Hippocampal subfield volumes: age, vascular risk, and correlation with associative memory. Frontiers in Aging Neuroscience, Front Aging Neurosci. 2011 Feb 4;3:2

Raz, N., Yang, Y., Dahle, C.L., Land, S. (2012). Volume of White Matter Hyperintensities in healthy adults: Contribution of age, vascular risk factors, and inflammation-related genetic variants. BBA: Biochimica et Biophyisica Acta, Section: Molecular Basis of Disease., 1822, 361-369, 2011 Aug 25. [Epub ahead of print].

Bender, A.R. & Raz, N. (2012). Advanced age, reduced working memory performance, and metamemory beliefs contribute to associative recognition deficit in healthy adults. Psychology and Aging, 27(3):691-700. Epub 2012 Jan 16.

Bender, A.R., & Raz, N. (2012). Age-related differences in memory and executive functions in healthy APOE e4 carriers: The contribution of individual differences in prefrontal volumes and systolic blood pressure. Neuropsychologia, 50, 704-714.

Bender, A.R. & Raz, N. (2012). Age-related differences in episodic memory: A Synergistic contribution of genetic and physiological vascular risk factors. Neuropsychology, 26(4):442-50. Epub 2012 May 21.

Alosco, M.L., Brickman, A.M., Spitznagel, M.B., Griffith, E.Y., Narkhede, A., Raz, N., Cohen, R., Sweet, L.H., Colbert, L.H., Josephson, R., Hughes, J., Rosneck, J., & Gunstad, J. (2013). Poorer physical fitness is associated with reduced structural brain integrity in heart failure. Journal of the Neurological Sciences, 328(1-2):51-7. doi: 10.1016/j.jns.2013.02.015. Epub 2013 Mar 23.

Alosco, M.L., Brickman, A.M., Spitznagel, M.B., Griffith, E.Y., Narkhede, A., Raz, N., Cohen, R., Sweet, L.H., Colbert, L.H., Josephson, R., Hughes, J., Rosneck, J., & Gunstad, J. (2013). The Adverse impact of Type 2 diabetes on brain volume in heart failure. Journal of Clinical and Experimental Neuropsychology, 35(3):309-318.

Daugherty, A.M., & Raz, N. (2013). Age-Related differences in iron content of subcortical nuclei observed in vivo:  A meta-analysis. NeuroImage, 70:113-121. doi: 10.1016/j.neuroimage.2012.12.040. Epub 2012 Dec 28.

Alosco, M.L., Spitznagel, M.B., Raz, N., Cohen, R., Sweet, L.H., Colbert, L.H., Josephson, R., van Dulmen, M., Hughes, J., Rosneck, J., & Gunstad, J. (2013). Obesity interacts with cerebral hypoperfusion to exacerbate cognitive impairment in older adults with heart failure. Cerebrovascular Diseases EXTRA. 2(1):88-98. doi: 10.1159/000343222. Epub 2012 Oct 25.

Raz, N., Schmiedek, F., Rodrigue, K.M., Kennedy, K.M, Lindenberger, U., & Lövdén, M. (2013). Differential brain shrinkage over six months shows limited association with cognitive practice, Brain and Cognition, 82(2):171-80. doi: 10.1016/j.bandc.2013.04.002. Epub 2013 May 11.

Fjell, A.M., Westlye, L.T., Grydeland, H., Amlien, I., Espeseth, T., Reinvang, I.,  Raz, N., Holland, D., Dale, A.M., Walhovd, K.B. the Alzheimer Disease Neuroimaging Initiative. (2013). Critical ages in the life-course of the adult brain: nonlinear trends in subcortical aging. Neurobiology of Aging, 34(10):2239-2247. doi: 10.1016/j.neurobiolaging.2013.04.006.Epub 2013 May 2.

Rodrigue, K.M., Daugherty, A.M., Haacke, E.M., & Raz, N. (2013). The role of hippocampal iron concentration and hippocampal volume in age-related differences in memory performance, Cerebral Cortex, 23:1533-1541. doi: 10.1093/cercor/bhs139. Epub 2012 May 29.

Bender, A.R., Daugherty, A.M., & Raz, N. (2013). Vascular risk moderates associations between hippocampal subfield volumes and memory. Journal of Cognitive Neuroscience, 25:11,1851–1862. doi:10.1162/jocn_a_00435Jun 14. [Epub ahead of print].

Raz, N. & Lindenberger, U. (2013). Life-Span Plasticity of the brain and cognition: From questions to evidence and back. Neuroscience and Biobehavioral Reviews. 2013, Oct 15, 37(9 Pt B):2195-200. DOI:10.1016/j.neubiorev.2013.10.003. Epub 2013 Oct 15.

Alosco, M.L., Brickman, A.M., Spitznagel, M.B., Griffith, E.Y., Narkhede, A., Raz, N., Cohen, R., Sweet, L.H., Hughes, J., Rosneck, J., & Gunstad, J.  (2013). The independent and interactive effects of systolic blood pressure and cardiac function on brain volume and white matter hyperintensities in heart failure. Journal of the American Society of Hypertension, 7(5):336-43. doi: 10.1016/j.jash.2013.04.011. Epub 2013 Jun 2.

Alosco, M.L., Brickman, A.M., Spitznagel, M.B., Garcia, S.L., Narkhede, A., Griffith, E.Y., Raz, N., Cohen, R., Sweet, L.H., Colbert, L.H., Josephson, R., Hughes, J., Rosneck, J., & Gunstad, J. (2013). Cerebral perfusion is associated with White Matter Hyperintensities in older adults with heart failure. Congestive Heart Failure, 19(4):E29-34.

Fjell AM, Westlye LT, Grydeland H, Amlien I, Espeseth T, Reinvang I, Raz N, Dale AM, Walhovd KB. (2014). Accelerating cortical thinning: unique to dementia or universal in aging?  Cerebral Cortex, 24(4):919-34. doi: 10.1093/cercor/bhs379.Epub 2012 Dec 12.

Alosco ML, Spitznagel MB, Cohen R, Raz N, Sweet LH, Josephson R, Hughes J, Rosneck J, Gunstad J.  (2014).Reduced cerebral perfusion predicts greater depressive symptoms and cognitive dysfunction at a 1-year follow-up in patients with heart failure. International Journal of Geriatric Psychiatry. 29(4):428-36. doi: 10.1002/gps.4023. Epub 2013 Sep 10.

Raz, N. & Lustig, C. (2014). Genetic variants and cognitive aging: Destiny or a nudge? Psychology and Aging, 29(2):359-362. doi: 10.1037/a0036893.

Yuan, P. & Raz, N. (2014). Prefrontal cortex and executive functions in healthy adults: A Meta-analysis of structural neuroimaging studies. Neuroscience and Biobehavioral Reviews, 42C:180-192. doi: 10.1016/j.neubiorev.2014.02.005.[Epub ahead of print].

Yuan, P., Daugherty, A.M., Raz, N. (2014). Turning bias in virtual spatial navigation: Age-related differences and neuroanatomical correlates. Biological Psychology, 96:8-19. doi: 10.1016/j.biopsycho.2013.10.009.[Epub ahead of print].

Persson, N., Ghisletta, P, Dahle, C.L., Bender, A.R., Yang, Y., Yuan, P., Daugherty, A.M., Raz, N. (2014). Regional brain shrinkage over two years: Individual differences and effects of pro-inflammatory genetic polymorphisms. NeuroImage, 103, 334–348. 

 Yushkevich, P., Amaral, R.S.C, Austinack, J.C., Bender, A.R., Bernstein, J.D. Boccardi, M., Bocchetta, M., Burggren, A., Carr, VA,  Chakravarti, M.M., Chetelat, Daugherty, AM., Davachi, L., Ding, S.L., Ekstrom, A., Geerling. M., Hassan, A., Huang, Y., Iglesias, J.E., Kerchner, G.A., La Joie, R., LaRocque,, K.F.,  Libby, LA., Malykhin, N., Mueller, S.G., Palombo, D.J., Pruessner, J.C., Olsen, R.K., Parekh, M.B., Pluta,J.B., Preston, A.R., Ranganath, C., Raz, N., Schlichting, M.L. Schoemaker, D. , Singh, S., Stark, CEL., Suthana, N., Tompary A., Turowski, M.M., Van Leemput, K., Wagner, A.D., Wang, L., Winterborn, J.L, Wisse, L.E.M, Yassa, M.A., Zeineh, M.M. for the Hippocampal Subfields Group (HSG). (2015). Quantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal cortical subregions in in vivo MRI: Towards developing a harmonized segmentation protocol. NeuroImage, 111, 526-541. doi: 10.1016/j.neuroimage.2015.01.004.

Daugherty, A.M., Haacke, E.M., & Raz, N., Increase in iron content predicts shrinkage of the striatum and changes in verbal working memory in healthy adults. Journal of Neuroscience, 35(17):6731-6743.

Yang, Y., Bender, A.R., Raz, N. (2015). Age related differences in reaction time components and diffusion properties of normal-appearing white matter in healthy adults. Neuropsychologia, 66, 246-258.

Bender, A.R., & Raz, N. (2015). Normal-appearing cerebral white matter in healthy adults: Mean change over two years and individual differences in change. Neurobiology of Aging, 36, 1834-1848.

Raz, N. Daugherty, AM., Bender, A.R., Dahle, C.L., & Land, S. (2015). Raz, N. Daugherty, AM., Bender, A.R., Dahle, C.L., & Land, S. (2015). Volume of the hippocampal subfields in healthy adults: differential associations with age and a pro-inflammatory genetic variant. Brain Structure and Function, 220(5), 2663-2674; 2014 Jun 20. [Epub ahead of print]..

Daugherty, A.M., Yuan, P., Dahle, C., Bender, A.R., Yang, Y., & Raz, N. (2015). Path complexity in virtual water maze navigation: Differential associations with age, sex, and regional brain volume. Cerebral Cortex, 25(9), 3122-3131; 2014 May 23 [Epub ahead of print]

Daugherty A. & Raz, N. (2015). Appraising the role of iron in brain aging and cognition: Promises and Limitations of MRI Methods Neuropsychology Review, 25, 272–287.

Bender, A.R., Voelkle M.C., & Raz, N. (2016). Differential aging of the white matter in middle-aged and older adults: A seven-year follow-up. NeuroImage, 125, 74-83. 

Persson, N., Ghisletta, P, Dahle, C.L., Bender, A.R., Daugherty, A.M., Yang, Y., Yuan, P., & Raz, N. (2016). Regional brain shrinkage and change in cognitive performance over two years: The bidirectional influences of the brain and cognitive reserve factors. NeuroImage, 126, 15-26.  

Bender, A.R., Prindle, J.J., Brandmaier, A.M., & Raz, N. (2016). White matter and memory in healthy adults: Coupled changes over two years. NeuroImage, 2015 Nov 3, [Epub ahead of print].

Daugherty, A.M., Bender, A.R., Yuan, P., Raz, N. (2015). Changes in search path complexity and length during learning of a virtual water maze: Age differences and differential associations with hippocampal subfields volumes. Cerebral Cortex, 2015 Apr 1. [Epub ahead of print].

 Daugherty, A.M., Bender, A.R., Raz, N., & Ofen, N.  (2016). Age differences in hippocampal subfield volumes from childhood to late adulthood. Hippocampus, 2015 Aug 19. doi: 10.1002/hipo.22517.[Epub ahead of print].

Book Chapters

Raz, N. (2000). Aging of the brain and its impact on cognitive performance: Integration of structural and functional findings. In: F.I.M. Craik and T.A. Salthouse (Eds.) Handbook of Aging and Cognition - II. (Pp.1-90). Mahwah, NJ: Erlbaum.

Raz, N. (October 2001). Ageing and the Brain. In: Encyclopedia of Life Sciences, London: Nature Publishing Group, http://www.els.net/doi:10.1038/npg.els.0003375  

Raz, N. (2005).The aging brain observed in vivo: Differential changes and their modifiers. In R. Cabeza, L. Nyberg, & D. C. Park (Eds.), Cognitive Neuroscience of Aging: Linking Cognitive and Cerebral Aging. New York: Oxford University Press, pp.17-55.

Raz, N. & Kennedy, K.M. (2009). A systems approach to age-related change: Neuroanatomic changes, their modifiers, and cognitive correlates. In: W. Jagust, & M. D’Esposito. Imaging the Aging Brain. (Eds.) New York, NY: Oxford University Press, pp. 43-70.

Kennedy K.M., & Raz N. (2015) Normal Aging of the Brain. In: Arthur W. Toga, editor. Brain Mapping: An Encyclopedic Reference, vol. 3, pp. 603-617. Academic Press: Elsevier.          

Presentations

Recent Conference Presentations (2013-2016).

Persson, N., Bender, A.R., Yuan, P., Yang, Y., Dahle, C.L., Daugherty, A.M., & Raz, N Differential age-related changes in regional brain volumes in a span of less than two years. Presented at the Annual Meeting of the Society for Neuroscience, San Diego, CA 2013.

Bender, A.R., & Raz, N. Cerebral white matter change predicts associative memory performance and effects of repeated testing in healthy adults. Presented at the Annual Meeting of the Society for Neuroscience, San Diego, CA 2013.

Raz, N., Daugherty, A.M., & Bender, A.R. Volume of hippocampal subfields in healthy adults: Age differences and the effects of genetic and physiological markers of neuroinflammation. Presented at the Annual Meeting of the Society for Neuroscience, San Diego, CA 2013.

Bender, A.R. & Raz, N. Individual differences in cerebral white matter predict retest effects in verbal recognition memory among healthy adults. Cognitive Aging Conference, Atlanta, GA, April 3, 2014.

Daugherty, A.M., Bender, A.R., Yuan, P., Dahle, C.L., Yang, Y., and Raz, N. Stability of Spatial Navigation in Aging after 2 Years: Procedural Skill or Memory? Cognitive Aging Conference, Atlanta, GA, April 4, 2014.

Daugherty, A.M., Yuan, P., Dahle, C.L., Bender, A.R., Yang, Y., and Raz, N. Path complexity in Virtual Water Maze navigation: Differential associations with age, sex, and regional brain volume. Cognitive Neuroscience Conference, Boston, MA, April 7, 2014.

Persson, N., Ghisletta, P, Bender, A., Yang, Y., Yuan, P., Dahle, C., and Raz, N. Cognitive ability and inflammation are associated with brain shrinkage in healthy adults. Cognitive Neuroscience Conference, Boston, MA, April 7, 2014.

Daugherty A.M. & Raz, N. Longitudinal Iron Accumulation is Associated with Regional Brain Shrinkage in Healthy Aging. Presented at the Annual Meeting of the Society for Neuroscience, Washington, DC, November 17 2014

Bender, A.R., & Raz, N. Metabolic syndrome risk mediates age-related changes in cerebral white matter: A Longitudinal Diffusion Tensor Imaging study. Presented at the Annual Meeting of the Society for Neuroscience, Washington, DC, November 16, 2014.

Raz, N (organizer). Zooming-in on the hippocampus: Advances in high-resolution imaging in the context of cognitive aging and dementia. A mini-symposium to be presented at Cognitive Neuroscience Society Conference, San Francisco, CA, March 27, 2015.

Raz, N. Aging of Human Brain and Cognition: Measurable Sex Differences? Presented at the Invited symposium and the annual meeting of the Organization for Study of Sex Differences, Palo Alto, CA, April 2015.

Arshad, M., Stanley, J.A., & Raz, N. Age Related Differences in Myelin Content Assessed Using Myelin Water Fraction Imaging. Presented at ISMRM Annual Meeting, Toronto, ON, Canada, June 2015

Damoiseaux, J.S., Viviano, R., Yuan, P. & Raz, N.  Adult age differences in functional connectivity in the default mode network. Presented at the Annual Meeting of human Brain Association, Honolulu, HI, June 2015.

Raz, N. Aging of the Brain: Its modifiers and cognitive correlates. Presented at an Invited Symposium at the annual meeting of Society for Neurobiology of Language, Chicago, IL, October 17, 2015.

Daugherty, A.M. & Raz, N. Iron accumulation over 7 years in the striatum predicts its shrinkage in healthy adults Presented at the Annual meeting of the Society for Neuroscience, Chicago, IL, October 19, 2015.

Bender, A.R., Voelkle, M. & Raz, N. Changes in white matter diffusion properties support the “last-in-first-out” hypothesis of brain aging. Presented at the Annual meeting of the Society for Neuroscience, Chicago, IL, October 20, 2015

Arshad, M., Stanley, J.A., & Raz, N. Age differences in regional myelin content and white matter organization in healthy adults: Comparing Myelin Water Fraction and Diffusion Tensor Imaging. Presented at the Annual meeting of the Society for Neuroscience, Chicago, IL. October 20, 2015.

Raz, N., Frames of mind: Do age-related changes in brain structure constrain cognitive performance in healthy adults? To be presented at the International congress of Psychology, Yokohama, Japan, July 2016.

Raz, N. Aging of the brain and cognition: What the time tells and what we are still waiting to hear. Invited address. To be presented at the International congress of Psychology, Yokohama, Japan, July 2016.